Start Date: | 10/13/2016 | Start Time: | 4:30 PM |
End Date: | 10/13/2016 | End Time: | 6:00 PM |
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Event Description
Simon Cocklin, PhD,
Drexel University College of Medicine
"Hopping Towards New HIV-1 Entry Inhibitors"
The entry of HIV-1 into permissive cells, facilitated by the Env complex, is a complex series of events and the inhibition of HIV-1 entry is an attractive, yet underexploited therapeutic approach. Using the combination of a field-derived bioactive conformation template to perform virtual screening and iterative bioisosteric replacements, coupled with in silico predictions of absorption, distribution, metabolism, and excretion, we have identified new leads for HIV-1 entry inhibitors. Moreover, we have characterized the mechanism of action of a representative compound and discovered that it likely functions via an allosteric mechanism to prevent conformational changes required for fusion/entry. These inhibitory compounds therefore represent novel reagents that can be used to probe the mechanism of entry of HIV-1 into the host cell and hold promise for the development of a new class of anti-HIV agents.
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Contact Information: Name: Hai-Feng (Frank) JI, PhD Phone: 215.895,2562 Email: hj56@drexel.edu |
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Location: Disque Hall, Room 109, 32 South 32nd Street, Philadelphia, PA 19104 |
Audience: Undergraduate StudentsGraduate StudentsFacultyStaff |
Special Features: Free Food |
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